The BEST Mac and Cheese Meatloaf Casserole is a delightful twist on two classic comfort foods. This dish combines the rich, cheesy goodness of mac and cheese with a savory meatloaf layer, making it perfect for family dinners or gatherings. Whether you’re looking for a hearty main course or a dish that brings everyone to the table, this casserole delivers both flavor and satisfaction.
Why You’ll Love This Recipe
- Comforting Flavor: The combination of cheesy macaroni and seasoned meatloaf creates a comforting meal that warms the heart.
- Easy Preparation: With straightforward steps, this recipe is suitable for both novice cooks and experienced chefs.
- Family Favorite: Kids and adults alike will enjoy the delicious blend of flavors, making it a surefire hit at any dinner table.
- Versatile Ingredients: Substitute ingredients based on preference or availability without compromising taste.
- Perfect for Leftovers: Enjoy the leftovers for lunch or dinner throughout the week; this casserole reheats beautifully.
Tools and Preparation
Before diving into this mouthwatering recipe, gather your tools to ensure a smooth cooking process. Having the right kitchen equipment on hand makes preparation easier.
Essential Tools and Equipment
- Baking dish (9×13-inch)
- Mixing bowl
- Medium saucepan
- Whisk
- Cooking pot
Importance of Each Tool
- Baking dish: This size ensures even cooking for layers without overflowing, making it ideal for casseroles.
- Mixing bowl: A large bowl allows for easy mixing of ingredients without spilling.
- Medium saucepan: Perfect for creating a creamy cheese sauce that blends well with macaroni.
- Whisk: Helps achieve a smooth cheese sauce by breaking up lumps in flour and milk.

Ingredients
A delicious and hearty casserole combining classic mac and cheese with a flavorful meatloaf layer, perfect for a comforting family meal.
For the Meatloaf Layer:
- 1 ½ pounds ground beef
- 1 cup breadcrumbs
- 1 egg
- ½ cup milk
- 1 small onion, finely chopped
- 1 teaspoon garlic powder
- 1 teaspoon salt
- ½ teaspoon black pepper
- ½ cup barbecue sauce (for topping)
For the Mac and Cheese Layer:
- 2 cups elbow macaroni
- 2 tablespoons butter
- 2 tablespoons all-purpose flour
- 2 cups milk
- 2 cups shredded cheddar cheese
- ½ teaspoon salt
- ¼ teaspoon paprika (optional)
How to Make The BEST Mac and Cheese Meatloaf Casserole
Step 1: Preheat the Oven
Preheat the oven to 375°F (190°C). Lightly grease your baking dish to prevent sticking.
Step 2: Prepare the Meatloaf Mixture
In a large bowl:
1. Combine ground beef, breadcrumbs, egg, milk, chopped onion, garlic powder, salt, and pepper.
2. Mix until everything is evenly combined.
Step 3: Form the Meatloaf Base
Press the meat mixture firmly into the bottom of your prepared baking dish to create an even layer.
Step 4: Add Barbecue Sauce
Spread barbecue sauce over the top of the meat mixture evenly.
Step 5: Bake the Meatloaf Layer
Bake in the preheated oven for 25 minutes to allow the meat to begin setting.
Step 6: Cook Macaroni
While baking:
1. Cook elbow macaroni according to package directions.
2. Drain and set aside once cooked.
Step 7: Make Cheese Sauce
In a medium saucepan over medium heat:
1. Melt butter.
2. Whisk in flour and cook for 1 minute while stirring constantly.
3. Slowly add milk while whisking until thickened into a smooth sauce.
Step 8: Add Cheese
Remove from heat and stir in shredded cheddar cheese until melted and creamy. Add salt and optional paprika if desired.
Step 9: Combine Macaroni with Cheese Sauce
Fold cooked macaroni into your cheese sauce until all pasta is well coated.
Step 10: Assemble Casserole
Spoon mac and cheese over the partially baked meatloaf layer, smoothing it into an even layer.
Step 11: Final Bake
Return to oven and bake for an additional 15-20 minutes until golden on top and bubbling.
Step 12: Cool Before Serving
Allow casserole to rest for about 5 minutes before slicing into portions and serving warm. Enjoy!
How to Serve The BEST Mac and Cheese Meatloaf Casserole
This hearty casserole is perfect for family dinners and can be served in various delightful ways. Here are some creative serving suggestions to elevate your meal experience.
Family Style
- Serve the casserole directly from the baking dish, allowing everyone to help themselves. This creates a warm and inviting atmosphere.
With a Fresh Salad
- Pair the casserole with a bright, fresh salad. A simple green salad with a light vinaigrette complements the richness of the dish perfectly.
Topped with Fresh Herbs
- Sprinkle freshly chopped parsley or chives on top before serving. This adds a pop of color and freshness that balances the flavors.
With Garlic Bread
- Serve alongside crispy garlic bread for a crunchy contrast. This combination enhances the comfort food experience.
As Leftovers
- Enjoy it as leftovers for lunch or dinner. The flavors meld beautifully overnight, making it even tastier the next day.
How to Perfect The BEST Mac and Cheese Meatloaf Casserole
Achieving the ultimate version of this casserole involves some simple techniques to enhance flavor and texture.
- Use Quality Ingredients: Choose high-quality ground beef and real cheddar cheese for richer flavor.
- Don’t Overcook Pasta: Cook elbow macaroni just until al dente; it will continue cooking in the oven.
- Customize Cheese Blend: Experiment with different cheeses like Monterey Jack or Gouda for a unique twist on classic mac and cheese.
- Let It Rest: Allowing the casserole to rest for about 5 minutes after baking helps it set, making slicing easier.
- Adjust Seasonings: Feel free to add more spices or herbs to tailor the flavor profile to your liking.
- Add Vegetables: Incorporate cooked vegetables like spinach or bell peppers into the mac and cheese layer for added nutrition and color.
Best Side Dishes for The BEST Mac and Cheese Meatloaf Casserole
A well-rounded meal can be achieved by pairing your casserole with complementary side dishes. Here are some excellent options:
-
Steamed Broccoli
A nutritious choice, steamed broccoli adds vibrant color and a healthy crunch to your meal. -
Coleslaw
Crisp coleslaw provides a refreshing contrast to the rich flavors of the casserole, enhancing the overall dining experience. -
Roasted Vegetables
Roasting seasonal vegetables brings out their natural sweetness, creating a delicious side that’s easy to prepare. -
Corn on the Cob
Sweet corn on the cob is a classic side that pairs wonderfully with comfort food like this casserole. -
Garlic Mashed Potatoes
Creamy garlic mashed potatoes add an extra layer of comfort, making your meal even heartier. -
Caesar Salad
A Caesar salad adds crunch and tanginess while balancing out the richness of mac and cheese meatloaf casserole. -
Sautéed Green Beans
Sautéed green beans provide a nice crunch and vibrant color, making them an excellent addition to any plate. -
Baked Sweet Potatoes
Baked sweet potatoes offer natural sweetness that contrasts beautifully with savory dishes like this casserole.
Common Mistakes to Avoid
When preparing The BEST Mac and Cheese Meatloaf Casserole, it’s easy to make a few common mistakes. Here are some to watch out for:
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Using dry meatloaf mixture: Ensure that your meat mixture is moist enough by adding sufficient milk and not overbaking it initially. This prevents a dry texture in the finished casserole.
-
Overcooking the macaroni: Cook the elbow macaroni just until al dente. It will continue to cook when combined with the cheese sauce and baked, so undercooking slightly helps maintain its texture.
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Not letting it rest: Allow the casserole to rest for about 5 minutes after baking. This helps it set and makes slicing easier, preventing a messy presentation.
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Skipping the sauce thickening step: When making the cheese sauce, whisk continuously to avoid lumps. A smooth sauce is key for evenly coating the macaroni.
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Ignoring flavor adjustments: Taste your meatloaf mixture and cheese sauce before baking. Adjust seasonings as needed for a more flavorful dish.

Storage & Reheating Instructions
Refrigerator Storage
- Store leftovers in an airtight container.
- Keep in the refrigerator for up to 3 days.
Freezing The BEST Mac and Cheese Meatloaf Casserole
- Use a freezer-safe container or wrap tightly with plastic wrap.
- Freeze for up to 3 months for best quality.
Reheating The BEST Mac and Cheese Meatloaf Casserole
- Oven: Preheat the oven to 350°F (175°C). Cover with foil and bake for about 20-25 minutes until heated through.
- Microwave: Place in a microwave-safe dish, cover, and heat on medium power in 1-minute intervals until hot.
- Stovetop: Heat slices in a skillet over medium-low heat for about 5-7 minutes, flipping occasionally until warmed through.
Frequently Asked Questions
Here are some common questions about The BEST Mac and Cheese Meatloaf Casserole:
Can I use ground turkey instead of beef?
Yes! Ground turkey is a great alternative that works well in this recipe while reducing fat content.
How can I customize my mac and cheese?
Feel free to add vegetables like spinach or bell peppers or even mix in different cheeses such as mozzarella or gouda for added flavor!
What can I serve with this casserole?
Pair it with a simple salad or steamed vegetables for a balanced meal that complements the rich flavors of the casserole.
Is it okay to prepare this ahead of time?
Absolutely! You can assemble everything ahead of time and refrigerate it until you are ready to bake. Just add a few extra minutes to the cooking time if baking from cold.
Final Thoughts
The BEST Mac and Cheese Meatloaf Casserole is not only comforting but also versatile. This dish combines two beloved favorites into one hearty meal that’s perfect for family dinners. Feel free to customize it with your favorite ingredients, making it an ideal weeknight dinner option that everyone will love!
The BEST Mac and Cheese Meatloaf Casserole
Indulge in a comforting and hearty meal with The BEST Mac and Cheese Meatloaf Casserole. This delightful dish combines the creamy, cheesy goodness of macaroni and cheese with a savory meatloaf layer, making it an ideal centerpiece for family dinners or gatherings. Each bite delivers a perfect balance of flavors, ensuring satisfaction for both kids and adults alike. With easy preparation steps and customizable ingredients, this casserole is not only delicious but also a breeze to make. Enjoy it fresh from the oven or savor the leftovers throughout the week—the flavors only get better!
- Total Time: 1 hour 5 minutes
- Yield: Serves 8
Ingredients
- 1 ½ pounds ground beef
- 2 cups elbow macaroni
- 2 cups shredded cheddar cheese
- 1 cup breadcrumbs
- 2 cups milk
- 1 egg
- ½ cup barbecue sauce
- 1 small onion, finely chopped
- 1 teaspoon garlic powder
- 1 teaspoon salt
- ½ teaspoon black pepper
- 2 tablespoons butter
- 2 tablespoons all-purpose flour
- ½ teaspoon salt
- ¼ teaspoon paprika (optional)
Instructions
- Preheat oven to 375°F (190°C) and grease a baking dish.
- In a bowl, mix ground beef, breadcrumbs, egg, milk, chopped onion, garlic powder, salt, and pepper until combined.
- Press the mixture into the baking dish and top with barbecue sauce; bake for 25 minutes.
- Cook elbow macaroni according to package instructions; drain.
- In a saucepan, melt butter; whisk in flour then slowly add milk until thickened. Stir in cheese until melted.
- Fold cooked macaroni into cheese sauce; pour over the meatloaf layer in the baking dish.
- Bake for an additional 15-20 minutes until golden and bubbly.
- Prep Time: 20 minutes
- Cook Time: 45 minutes
- Category: Main
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1/8 of casserole (approximately 230g)
- Calories: 450
- Sugar: 4g
- Sodium: 820mg
- Fat: 22g
- Saturated Fat: 10g
- Unsaturated Fat: 11g
- Trans Fat: 0g
- Carbohydrates: 37g
- Fiber: 2g
- Protein: 28g
- Cholesterol: 80mg